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Additionally it was noted that in the rats treated with AOD9604, there were increased rates of lipolytic activity, as well as no negative effect on insulin sensitivity which has been seen in animals treated with human growth hormone ( A similar study conducted by Heffernan et

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Furthermore, NRF2 expression was not decreased by BSO treatment, confirming the viability phenotype observed for BSO-treated cells and demonstrating that the downregulation of NRF2 expression by Cyss depletion is not dependent on GSH (Fig