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When MTX enters a cell through carriers referred to as human-reduced folate carriers (SLC19A1), polyglutamate synthetase attaches glutamate residues to the -carboxylate group of MTX, converting it into methotrexate polyglutamates (MTX-PGs)

10.1016/j.clnu.2005.10.005 22 D'OnofrioN.ServilloL.GiovaneA.CasaleR.VitielloM.MarfellaR.et al (2016)

Theres been no groundswell from our members about challenging these items, perhaps because they dont meet the criteria under 503A. Under Section 503A of the Food, Drug & Cosmetic Act, an eligible bulk drug substance for compounding must be a component of an FDA-approved drug, must have a USP or NF monograph, or must appear on FDAs 503A Bulks List or Interim Bulks List Category 1

"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency"

2022;34(4):e20210076