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Ipamorelin selectivity Raun et al., 1998 (Eur J Endocrinol): Ipamorelin produced GH release without elevating ACTH or cortisol, even at 200x the effective GH-releasing dose

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Unlike traditional single-target peptides, this compound simultaneously activates three distinct receptor pathways: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors [1]