why is the semaglutide not working for me 7 Reasons You Aren't Losing Weight on Weight Loss Drugs Why Semaglutide May Not Work:

A particular capability of semaglutide is to exert anti-inflammatory effects, possibly by inhibiting the expression of key factors in WAT inflammation S100a8, S100a9 and Cxcl2 in neutrophils [110,111]

Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor, the target for native GLP-1

Headache is also included among the common adverse reactions reported with Wegovy, a semaglutide product used for weight management

Seek immediate medical care if you develop any unusual or serious side effects

recent studies show that locally secreted GLP-1 can activate GLP-1 receptor-expressing afferent fibers of the glossopharyngeal and vagal nerves, thereby transmitting peripheral gustatory information to the NTS