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The concentration of glutathione is regulated by different processes, such as its own synthesis, its re-oxidation, its use for the detoxification of diverse substances (such as alcohol and drugs), and its transport to the different intracellular and extracellular compartments

In a series of trials, this same research group found that use of lithium reduced PKC in rat frontal cortex and hippocampus, suggesting that PKC inhibition may have antimanic efficacy

These results are consistent with previous findings [28, 30, 32]

Many patients administer both on the same day for convenience, while others space them throughout the week based on personal preference and symptom management

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