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However, the biological changes that lead to weight loss unfold gradually

This is where an important distinction comes into play, one that is central to our discussion on timing

Clinical trials evaluating the beneficial effect of vitamin C on cardiovascular disorders involve studies on endothelial dysfunction

At the onset, when clinical manifestations occur (hyperglycaemia, hypo-insulinaemia and the presence of circulating autoantibodies), individuals with type 1 diabetes still have some remaining functioning beta cells that persist for years after hyperglycaemia onset [2, 3]

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