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In -cells, the TATA box, as well as the adjacent G1 and G4 elements, represent the minimal promoter which is essential for Gcg expression while the elements G5, G2, G3, and CRE represent a more distal located enhancer region [94,[101], [102], [103]] (Figure 2)

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constructed double-layer coated liposomes with CS and chondroitin sulfate for delivering betanin, effectively improving the physicochemical stability of the liposomes and the cargo protective effects for betanin in different pH, ionic strength, and GI environments and achieving sustained release ( 2.2.2 Protein and peptide modification Introducing protein or peptide molecules with specific biological functions (e.g., adhesion proteins, enzymes, or cell-penetrating peptides (CPPs)) to the liposome surface can endow liposomes with properties such as mucus penetration, enhanced endocytosis, and active targeting

Most do not survive digestion in a form that produces the effect promised on the label