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In addition, LPS derived from the cell wall of Gram-negative bacteria in the gut activates inflammatory response through binding to toll-like receptor 4 (TLR4) on the mucosal immune cells, which is vital for maintaining gut microbiota homeostasis in normal physiology

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Protein binding was studied in serum from volunteers who received either oral or intravenous glipizide and found to be 98 to 99% one hour after either route of administration

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