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It is possible that CJC-1295 may also increase the risk of edema and joint discomfort due to higher water retention, similar to sermorelin

10.1210/en.2003-1236 Endocrinology 24 DelezieJ.ChalletE

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Draw Your Diluent: Using your larger reconstitution syringe, draw air into the syringe equal to the volume of BAC water you plan to use (e.g., draw 2mL of air if you're using 2mL of water)

Ynddal, Lars (1999).Pharmacokinetic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers"