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It has been indicated that SCFAs may improve energy homeostasis and fat storage via boosting fatty acid oxidation and thermogenesis through upregulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) and AMPK in the muscle and liver tissues

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On the other hand, immunosuppressive cytokines, such as TGF- and granulocyte-macrophage colony-stimulating factor (GM-CSF), were released to facilitate the recruitment of MDSCs or the suppression of antigen-presenting cells (APCs)

The increased serum concentration of 5-HT and the simultaneously decreased excretion of 5-HIAA can be attributed to the decreased activity of MAO (50, 54, 56)