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Rights and permissions About this article Cite this article Giel, K.E., Bulik, C.M., Fernandez-Aranda, F

The FDA approved sitagliptin, the first DPP-4i on the market, in 2006 and shortly after, numerous additional DPP-4i received market clearance

Our integrated omics analysis supports this receptor synergy by showing consistent downregulation of metabolic intermediates of fatty acid oxidation as well as pro-inflammatory and pro-fibrotic metabolites, confirming a unified pharmacodynamic effect across molecular and metabolic layers

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