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It is primarily used to reduce abdominal fat in HIV-infected patients with lipodystrophy, a condition characterized by abnormal fat distribution

For consistency, the study medication was always administered in the left nostril and spectra were collected ipsilaterally

Fenfluramine, one of the earliest weight loss drugs, was found over time to be associated with valvular heart disease [48] and was withdrawn from the market by the FDA

Recent studies have highlighted the pivotal role of the endothelial glycocalyx in systemic inflammatory diseases such as sepsis and atherosclerosis, where its degradation correlates with microcirculatory failure and organ dysfunction [8, 10, 13]

Heres why: Lipedema involves: Fibrosis (tight, rope-like tissue) Lymphatic congestion Increased microvascular fragility Chronic inflammation GLP-1 therapies do not correct those drivers even if someone loses weight