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In addition, NDDS can leverage the enhanced EPR effect to achieve passive targeting, effectively prolonging drug retention at the tumor site ( 4.3 Metabolism Certain drugs are rapidly metabolized and inactivated by hepatic enzymes due to first-pass metabolism

The excess TG usually deposits inside the cells of adipose tissues and the liver as lipid droplets [39]

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These findings suggest that IGF-1 plays a crucial role in preventing metabolic disorders and maintaining glucose homeostasis (Rajpathak et al., 2014)

Although necrosis and necroptosis are typically independent of the caspase cascade, ROS and Ca 2+ ions are key participants that do not directly relate to external stimuli in these two processes