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Tzang CC, Chi LY, Lin LH, et al

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It reviews their mechanisms of action, semaglutide acting as a GLP-1 receptor agonist and tirzepatide functioning as a dual GIP/GLP-1 receptor agonist, and explains how these pathways translate into clinical outcomes

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The anti-fibrotic effects of SGLT2i have been demonstrated in several CKD animal models [166,167,168,169] and in kidney tissue from patients with diabetic kidney disease receiving empagliflozin, partly due to the down-regulation of pyruvate kinase M2, the rate-limiting enzyme of glycolysis [170]