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The dual-agonist design was first characterized by Coskun and colleagues, who showed that a single peptide could engage both receptors with carefully tuned affinities (Coskun et al., Molecular Metabolism 2018

It creates receptor saturation dynamics that current pharmacokinetic models can't predict reliably

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Broad Connectivity Map analysis has revealed that GHK-Cu modulates the expression of over 4,000 human genes, representing approximately 6% of the genome

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