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Some patients may achieve adequate glycemic control or weight loss at this dose level, particularly those with mild metabolic dysfunction or those who are particularly sensitive to the medications effects

For a once-weekly peptide like semaglutide where consistent dosing drives therapeutic response, these errors accumulate over the life of the vial

Semaglutide and cardiovascular outcomes in patients with type 2 diabetes

GLP-1 medications (1522.5% body weight loss) are significantly more effective than phentermine (57%) over longer treatment courses

However, if split dosing improves your adherence and reduces side effects, the practical benefit may outweigh theoretical pharmacokinetic concerns