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doi: 10.3389/fimmu.2012.00288 219 MaesMCouckeFLeunisJC

This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

A related species, Rumex acetosa , has shown anti-HTN effects in rats through vasodilation (479)

This opens up the possibility of our gene therapy targeting the GSH system

Further, controlled clinical studies simulating NSW provide causal evidence that melatonin secretion diminishes rapidly upon night work exposure and remains suppressed with continued circadian disruption 183