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Trulicity (dulaglutide) is FDA-approved to treat type 2 diabetes and reduce cardiovascular risks, similar to Ozempic

Taken together, our present study was aimed to testify whether semaglutide could reverse LVH induced by pressure overload, and whether the effects of semaglutide on LVH were achieved by improving mitophagy dysfunction to suppress the activation of NLRP3 inflammasome

The atomic coordinates and electron microscopy maps have been deposited in the Protein Data Bank (PDB) under accession codes: 7FIY (tirzepatideGIPRG s complex), 7VAB (non-acylated tirzepatideGIPRG s complex), 7FIM (tirzepatideGLP-1RG s complex), 7VBI (non-acylated tirzepatideGLP-1RG s complex), 7FIN (peptide 20GIPRG s complex), 7VBH (peptide 20GLP-1RG s complex) and 7V35 (peptide 20GCGRG s complex), as well as Electron Microscopy Data Bank (EMDB) under accession codes: EMD-31606 (tirzepatideGIPRG s complex), EMD-31836 (non-acylated tirzepatideGIPRG s complex), EMD-31603 (tirzepatideGLP-1RG s complex), EMD-31880 (non-acylated tirzepatideGLP-1RG s complex), EMD-31604 (peptide 20GIPRG s complex), EMD-31879 (peptide 20GLP-1RG s complex) and EMD-31676 (peptide 20GCGRG s complex), respectively

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