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doi: 10.1093/jn/126.2.451

2004 Jul;11 Suppl 1:S73-85

Preliminary results on 30 patients showed a 42% improvement in the ECCA scarring score after three sessions of microneedling combined with GHK-Cu + PRP, versus 28% with PRP alone

This decline accelerates during perimenopause and menopause in women due to estrogens role in NAD+ synthesis