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doi:10.1093/oxfordjournals.jbchem.a122779

in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1659-1679 (Springer, 2022)

Blood NADs and Glutathione Metabolites are Perturbed in Various Diseases To explore whether the redox pools were modified by chronic age-related diseases, we examined blood NAD and glutathione metabolites across 11 different diseases, including various cancer types, diabetes (Type II) and neurodegenerative diseases (Parkinsons and Alzheimers)

It was also found that the Michaelis constant (Km = 1.2 10 5 M) of FSP1 was relatively low, and the maximum reaction rate (Vmax = 4.1 10 7 M s 1) was much higher than that of related oxidoreductases, indicating that efficiency of FSP1