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Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats
GLP-1 signaling also antagonizes voltage-dependent K + (Kv) channels via cAMP/PKA-dependent pathway in beta cells, which prevents beta-cell repolarization by reducing Kv currents
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Later, it also gained approval for weight management
Typically, the dose is increased every month until a long-term maintenance dose is reached, but the timeframe can be customized to your needs
