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These are some major goals that need radical changes

How long does it take to see effects in animal research models

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Convenient dosing: A single weekly subcutaneous dose is easier to stick with than daily regimens [1]

I never find a clear physical explanation, and I feel that leaves us with an interesting question as to whether Mpemba-like effects exist in a meaningful way. Bechhoefers trials appear to offer some insight into how the Mpemba effect could arise in systems with metastable states, but whether it is the only mechanism or how any particular substance undergoes such out-of-equilibrium heating or cooling is unknown