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Its critical because we typically dont develop therapeutics for psychiatric disorders unless we are convinced they have some degree of relevant access to the brain regions that are subserving the pathology that defines the condition, like reward, motivation, cognition

EVOKE+ nevertheless showed favorable shifts in Alzheimers-related biomarkers, indicating meaningful biological engagement and sharpening the fields focus toward earlier intervention, better patient selection, and improved brain delivery

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10.1001/jamainternmed.2016.1531 9 HeL.WangJ.LiZ.LiY.ZhangH