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Tesamorelin enters the protocol first, with the goal of reducing the visceral pattern before adding muscle-targeting peptides

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GHRH is the primary physiological regulator of pulsatile pituitary GH secretion, as evidenced by suppression of GH secretion upon GHRH gene silencing or anti-GHRH antibody administration

It doesn't help because the problem isn't on the surface

However, these comparisons should be interpreted with caution, as the available data are derived from trials with heterogeneous study designs, durations, endpoints, and patient populations