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Microneedling creates micro-channels that may increase GHK-Cu absorption by up to 20 times compared with topical application alone

The cGMP that is produced via NO activation of soluble guanylate cyclase (sGC) in this tissue is degraded by a specific cyclic nucleotide phosphodiesterase (PDE) identified as PDE5A

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The 0.01% retinal component provides gentle but effective anti-aging benefits, making this an ideal choice for those who want to start their retinoid journey without risking the redness, peeling, or discomfort that can come with stronger formulations