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In sensitivity analyses, see Table 3, GLP-1 RA use was associated with lower risk compared with SGLT-2 inhibitors among patients without a recent psychiatric history, but no difference was observed among patients with recent psychiatric history

Naylor, J

Conclusions In summary, GLP-1RAs offer a promising therapeutic strategy for type 2 diabetes patients, especially those with or at risk for early CKD

Similarly, in vitro experiments, approximately 45 bacterial phylotypes were identified to enhance GLP-1 secretion through exposure of NCI H716 L-cells to their cell-free culture supernatants (Tomaro-Duchesneau et al., 2020), co-incubation of Caco-2 cells with Enterococcus faecalis or Mitsuokella multacida supernatants led to a significant reduction in GLP-1 mRNA expression ( E

Reference: Bjrn Pasternak, Viktor Wintzell, Anders Hviid, Bjrn Eliasson, et al