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10.1016/j.fct.2023.113846 Food Chem

Illustratively, BPC 157 counteracted lidocaine convulsions [60], and thereby, likely also lidocaines effects on the central nervous system (i.e., inhibiting nicotinic acetylcholine receptors, inhibiting presynaptic calcium channels in the dorsal root ganglion, inhibiting opioid receptors, inhibiting of neurite growth, inhibiting muscarinic cholinergic receptors, and preventing substance P from binding to natural killer (NK) cell receptors) [278,281,282,283]

Induction of P-glycoprotein can result in decreased intestinal absorption of cationic drugs, reduced entrance into the CNS across the blood-brain-barrier, and increased secretion of drugs into renule tubules

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And the research outcomes that depend on them