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Moreover, small prospective trials demonstrated that metformin reduces left ventricular (LV) mass and improves diastolic function and myocardial energetics, suggesting favorable effects on cardiac remodeling central to DCM pathophysiology (Mohan et al., 2019)

Arias-Negrete S, Keller K, Chadee K (1995) Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages

Accordingly, selective targeting of GSH-dependent nodes (such as cysteine transport, mitochondrial GSH import, compartmentalized GSH degradation, or NADPH-dependent regeneration) may offer greater specificity and efficacy than indiscriminate redox perturbation

Frontiers in Pharmacology, 13 , 1026182

Figure 1) is mainly produced by the kidney (Olson et al., 2008) and GPX3 was detected in human CSF (Solovyev et al., 2013