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At the same time, this covalent connection exhibits excellent stability in the in vivo environment and is not easily affected by other media

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stiffness and resistance to limb movement caused by increased muscle tone and/ gait and posture disturbances such as festination (rapid shuffling steps and a forward-flexed posture when walking), speech and swallowing disturbances including voice disorders, masklike face expression or small handwriting, although the range of possible motor problems that can appear is large