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PPAR/ antagonist GSK0660 rescued the decrease of brain-derived neurotrophic factor and tropomyosin receptor kinase B expression and reduced oxidative stress by activating CREB [192]

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RNA sequencing analysis revealed the activation of the Wnt/LRP5/-catenin signaling pathway

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Weight loss stabilizes after 12 to 18 months, but insulin sensitivity, blood sugar control, blood pressure, and lipid levels remain improved