glp 1 vs sglt2 weight loss GLP-1-based therapies for type 2 diabetes: from single, dual and triple agonists to endogenous GLP-1 production and L-cell differentiation | Diabetology & Metabolic Syndrome GLP-1R Agonists for Weight Loss

The FDA-approved titration schedule begins at 2.5 mg weekly for 4 weeks, then increases by 2.5 mg increments every 4 weeks as tolerated, up to a maximum of 15 mg weekly

Metformin acts on two different molecular pathways to enhance adult neural precursor proliferation/self-renewal and differentiation

Recent studies have indicated that the protective properties against endothelial dysfunction, anti-inflammatory effects on macrophages and the anti-proliferative action on smooth muscle cells may contribute to atheroprotection through GLP-1R signaling

Retatrutide on the plotter: the triple agonist difference Retatrutide adds a fascinating new dimension to GLP-1 plotting because it activates three receptors rather than one or two

The phase 2 study to evaluate the efficacy, safety and tolerability of maridebart cafraglutide is currently ongoing (ClinicalTrials.gov number, NCT05669599)