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Dosage, Timing, and How Long to Take It Human trials have used doses from 250 mg/day to 1,000 mg/day

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A 47-year-old woman with type 2 diabetes on an insulin pump began tirzepatide

Tirzepatide-Specific Safety Considerations GI symptoms are generally mild to moderate Risk of hypoglycemia when used with insulin or sulfonylureas Rare risk of pancreatitis (class effect) Possible thyroid C-cell effects (class warning) Heart rate increases have been documented, but are generally modest Retatrutide-Specific Safety Considerations Higher overall rate of side effects compared to tirzepatide in Phase 2 data More pronounced heart rate increase this is a dose-dependent effect directly related to glucagon receptor activation (glucagon is known to increase heart rate in pharmacological doses) At 12 mg doses, some participants experienced increases in heart rate of 46 bpm above baseline

I took prednisone two times last summer when I was in Hawaii and Mexico to prevent this rash from forming