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It is important to further dissect the role of aSYN in regulating dopaminergic neurotransmission and in defining the characteristics of dopaminergic neurons, at a cellular and molecular level, that lead to their preferential neurodegeneration in PD

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The immunoblotting and immunofluorescence microscopy detection demonstrated that only GSTP-S184D entered the nucleus in LPS-untreated RAW264.7 cells, and LPS triggered GSTP (WT) but not GSTP-S184A to enter the nucleus (Figures 5B,C)

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