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The 2022 ADA/EASD consensus report notes that "the magnitude of gastric emptying delay with once-weekly GLP-1 RAs is clinically smaller than with short-acting formulations, but it is not zero" [4]

However, maintaining lean mass is crucial for metabolic health

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Caloric restriction itself can influence temperature regulation

The number of treated obesity cases in Japan has been steadily increasing, with approximately 150,000 treated adult cases and approximately 180 treated children cases in 2025