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Astaxanthin can reduce the expression of NMDARs and AMPARs, regulate Ca 2+ dynamics, and inhibit abnormal depolarization of mitochondrial membrane potential ( m ) and ROS production [85, 86]

As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19