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Ideal candidates typically have a BMI of 27 or higher, or a BMI of 25+ with weight-related health conditions

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Clinical Evidence Pivotal Studies and Randomized Controlled Trial Evidence Description of Studies Study 023 was a phase III, open-label trial with a 14-week, randomized, double-blind, placebo-controlled period followed by a 52-week, open-label period that aimed to evaluate the efficacy and safety of setmelanotide (1 mg to 3 mg daily by subcutaneous [SC] injection) in patients aged greater than or equal to 6 years with BBS or Alstrm syndrome (AS) and obesity

However, it is still unclear which species of gut bacteria contributed to TMAO formation

Thomsen RW, Pedersen L, Mller N, Kahlert J, Beck-Nielsen H, Toft Srensen H