does tirzepatide work better than semaglutide for weight loss vs. Semaglutide vs Tirzepatide for Weight

In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind

Medically Reviewed on 1/14/2026 Am J Clin Nutr

No Phase III anti-inflammatory endpoint

Smaller portions and avoiding high-fat foods provides relief

Kirkegaard H, Bliddal M, Stvring H, Rasmussen KM, Gunderson EP, Kber L, et al