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It reflects the biological reality that obesity involves neurological and hormonal mechanisms that do not reset simply because you lost weight

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J Plant Physiol 162:291299 Turner LB, Pollock CJ (1993) The effects of temperature and Ph on the apparent Michaelis constant of glutathione-reductase from maize ( Zea mays L.)

These are not insignificant numbers, and anyone starting a retatrutide protocol for weight loss needs to understand them upfront