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Metabolic outcomes and safety of GLP-1 receptor agonists in children and adolescents with obesity: A systematic review and meta-analysis

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Islet isolation and glucose-stimulated insulin secretion Pancreatic islets were isolated through collagenase digestion of the pancreas, followed by gradient purification to obtain intact islets

Importantly, these studies are unable to control for key confounders of cancer risk and this dataset is inherently prone to multiple types of bias