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Clinical Evidence Extends Beyond Weight Loss: Cardiovascular outcomes data are reinforcing obesity as a chronic cardiometabolic disease requiring long-term treatment

This results in increased NO bioavailability, improved oxidative stress, and enhanced coronary blood flow in diabetic rats [104]

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Resveratrol pretreatment decreases ischemic injury and improves neurological function Via sonic hedgehog signaling after stroke in rats

Beyond weight loss, GLP-1 medications improve several metabolic risk factorsincluding fasting glucose, HbA1c, and triglyceridesthat independently correlate with blood pressure