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Older anti-obesity medications such as orlistat functioned mainly through local gastrointestinal mechanisms, inhibiting fat absorption and resulting in a weight loss of 23% (Bansal et al

Heart rate monitoring is advisable

Although the body typically has sufficient vitamin B 12 stores to last 3-5 years, once PA has been established the lack of absorption of new vitamin B 12 is compounded by the loss of the vitamin because of negative balance

In the brain, GLP-1 secreted from intestinal cells can be absorbed into the brain, and GLP-1 secreted from neurons remains in the CSF (Cabou and Burcelin, 2011)

Jain et al., 2020)