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Microglia lactylation in relation to central nervous system diseases

Inflammation is necessary for healing, but when it becomes chronic or excessive, it delays recovery

Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

There is no solid proof that B12 shots cause weight loss in people who are not deficient

During tumor progression, macrophage-derived TGF-1 can inhibit transcription through SMAD signaling, thereby promoting ferroptosis (93), particularly facilitating tumor cell extravasation and growth in secondary sites