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Carbonyl cyanide- p -trifluoromethoxyphenylhydrazone (FCCP)-stimulated respiration was lower than ADP-stimulated respiration, a pattern observed when FCCP or substrates become limiting and previously reported in Seahorse assays using isolated mitochondria 6,14

hiu r hn v GHK-Cu l g chng ta cn hiu ng li nh ngha ca Peptides v nguyn t ng (Cu)

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8 weeks (2/wk): ~6 vials 12 weeks (2/wk): ~8 vials 12 weeks (3/wk): ~12 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 12 weeks (2/wk): ~24 syringes 12 weeks (3/wk): ~36 syringes Bacteriostatic Water (10 mL bottles) Use 3.0 mL per 600 mg vial for reconstitution

The study was approved by the Institutional Review Board at the University of Kansas Medical Center (KUMC, Kansas City, KS, United States) and registered at www.ClinicalTrials.gov as NCT02957422