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Sedentary lifestyle: lack of physical activity aggravates cellulite, and is also harmful to health

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148 This has led to the development of the web-based metalation calculator tool, which allows a user to input known metal binding equilibrium constants for their protein of interest and calculates the degree to which that protein will metalated with a particular metal in an idealized cytoplasm. 146,152 The lack of an unbiased validation of the predictions of this model, however, remains both a significant limitation and a considerable analytical challenge, for two reasons

doi: 10.1016/j.jsbmb.2019.105521