We then address the limitations and safety concerns associated with GLP-1 agonism
in the genetic disorder Refsum disease, this system is impaired and phytanic acid accumulates in the plasma lipids
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The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )
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