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De Felice et al., 2012

Ageing and age-associated GH decline research GH pulse amplitude and frequency decline progressively with age a phenomenon termed somatopause associated with reduced GHRH drive and increased somatostatin tone

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Repeated administration of any synthetic peptide can provoke antibody formation, and the chronic dosing schedules sold by clinics have not been characterised in humans for this molecule [9]

As of June 2025, the FDA removed both semaglutide and tirzepatide from its drug shortage list, a move that limits when and how pharmacies can legally compound these medications