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Thus, these findings suggest that genistein (and possibly other Nrf-activating agents) coordinately upregulate both the cosubstrate (GSH) and enzyme (GPx-1 or GPx-2) necessary for hydrogen peroxide reduction, thereby contributing to the overall antioxidant capacity of the cell

However, these effects are gradual and vary between individuals

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In glaucoma, the progressive deterioration of the optic nerve is caused by loss of a specific neuronal population known as retinal ganglion cells (RGC), such that the condition has been classified as a neurodegenerative disease (85)