If side effects are the issue, a dose reduction is usually safer than a full stop
There is an urgent need for a pharmacological agent that can specifically and safely correct the shared metabolic pathology, ideally by acting at both central (e.g., controlling appetite and cravings) and peripheral (e.g., improving insulin sensitivity, reducing hepatic fat and inflammation) levels to support and enhance existing behavioral strategies, thereby lowering the risk of advanced liver disease development across metabolic and alcoholic etiologies
COCOA EXTRACT COULD SLOW AGING PROCESS IN OLDER ADULTS, 'PROMISING' NEW STUDY FINDS "While we anticipated that PPO might influence the flavanol content and absorption from smoothies, we were surprised by how quickly and significantly the addition of just one banana reduced flavanol content in the smoothie and, consequently, the levels of flavanols in the body," Ottaviani said
Potential drawbacks also exist
Weight loss is a primary driver of downstream hormonal benefits, with semaglutide producing up to 15% body weight reduction over 68 weeks and a 2025 trial reporting a mean loss of 5.6 kg, compared with 2.3 kg with other treatments
