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More than 4 million items of tirzepatide and semaglutide were dispensed on the NHS in England in 2025/2026 1 , while around 2.5 million people each month accessed GLP-1s privately at the end of 2025, according to James Kingsland, chair of the Digital Clinical Excellence (DiCE) network of primary care digital health providers

A total of 992 patients were identified as using an SGLT2i without ever having been prescribed a GLP-1 RA

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"Difficult tradeoffs exist for patients and plan sponsors alike," Faust said

doi:10.3389/fendo.2020.00178 Lo CWH, Fei Y, Cheung BMY