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A portfolio of drugs can be aggregated across this framework to produce a total LOE exposure figure: the difference between the un-adjusted portfolio NPV (assuming no LOE erosion) and the IP-adjusted NPV (applying expected erosion to each asset)
However, in the brain of neurodegenerative diseases, the excess production of ROS and NO results in neuronal damage 7,8,9
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Ann Diagn Pathol 9:1623
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